Analyzing the effects of the Spanish Civil War on biological well-being through new anthropometric indicators.

Numerous studies have demonstrated the negative impact of severe economic shocks (such as those associated with wars) on the growth of children and adolescents. Individuals exposed to these shocks during their developmental years exhibited shorter average heights compared to both previous and subsequent generations. Anthropometric research has highlighted the sensitivity of the height variable in understanding the biological well-being of children and adolescents. However, little attention has been paid to the evolution of other anthropometric variables. This study investigates the impact of the famine following the Spanish Civil War on biological well-being in nine municipalities of the Region of Valencia (with over 120,000 observations of individuals born between 1890 and 1955) using two indicators: chest circumference, and the percentage of individuals of short stature. Our findings confirm that both of these anthropometric indicators were responsive to the economic shock of the Civil War. The well-being levels prior to the war took 20 years to recover.

Height and political activism in rural Aragón (Spain) during the 20th century. A new perspective using individual-level data.

This article explores the relationship between the political leanings of more than 1000 men born in the 1870-1970 s in 11 rural Aragonese villages and their biological well-being during childhood and adolescence, proxied by height. The aim is to test whether an individual was more likely to be left-wing if his level of biological well-being was lower and, therefore, with more incentives to fight against the social inequality that had negatively affected his family. Our results confirm that, for most of the study period, there was a strong relationship between shorter height and political activism1 in left-wing parties and organizations.

Microenvironmental Snail1-induced immunosuppression promotes melanoma growth.

Melanoma is an aggressive form of skin cancer due to its high metastatic abilities and resistance to therapies. Melanoma cells reside in a heterogeneous tumour microenvironment that acts as a crucial regulator of its progression. Snail1 is an epithelial-to-mesenchymal transition transcription factor expressed during development and reactivated in pathological situations including fibrosis and cancer. In this work, we show that Snail1 is activated in the melanoma microenvironment, particularly in fibroblasts. Analysis of mouse models that allow stromal Snail1 depletion and therapeutic Snail1 blockade indicate that targeting Snail1 in the tumour microenvironment decreases melanoma growth and lung metastatic burden, extending mice survival. Transcriptomic analysis of melanoma-associated fibroblasts and analysis of the tumours indicate that stromal Snail1 induces melanoma growth by promoting an immunosuppressive microenvironment and a decrease in anti-tumour immunity. This study unveils a novel role of Snail1 in melanoma biology and supports its potential as a therapeutic target.

Selective NO2 Detection of CaCu3Ti4O12 Ceramic Prepared by the Sol-Gel Technique and DRIFT Measurements to Elucidate the Gas Sensing Mechanism.

NO2 is one of the main greenhouse gases, which is mainly generated by the combustion of fossil fuels. In addition to its contribution to global warming, this gas is also directly dangerous to humans. The present work reports the structural and gas sensing properties of the CaCu3Ti4O12 compound prepared by the sol-gel technique. Rietveld refinement confirmed the formation of the pseudo-cubic CaCu3Ti4O12 compound, with less than 4 wt% of the secondary phases. The microstructural and elemental composition analysis were carried out using scanning electron microscopy and X-ray energy dispersive spectroscopy, respectively, while the elemental oxidation states of the samples were determined by X-ray photoelectron spectroscopy. The gas sensing response of the samples was performed for different concentrations of NO2, H2, CO, C2H2 and C2H4 at temperatures between 100 and 300 °C. The materials exhibited selectivity for NO2, showing a greater sensor signal at 250 °C, which was correlated with the highest concentration of nitrite and nitrate species on the CCTO surface using DRIFT spectroscopy.

The effect of height on family formation in rural Spain, birth-cohorts 1835-1975.

This article examines the relationship between the height of adult males and marital outcomes, including likelihood of marrying, age at marriage, and marital fertility, in rural Spain. For this analysis, a sample of 4,501 men born between 1835 and 1975 living in 14 villages in northeastern Spain was taken. Previous research has shown that shorter individuals are less likely to marry. However, it is still disputed whether differences exist in the timing of marrying based on height, and little attention has been paid to the effect(s) of height on offspring. Family data were obtained from parish records and interviews with individuals and their families, while height data were obtained from military records, with individuals in Spain being conscripted at the age of 21 years. The data were linked according to nominative criteria using family reconstitution methods. The results confirm that shorter individuals were less likely to marry. Individuals of medium and medium-high height were the first to marry, with a small gap between them and shorter individuals. With regard to marital fertility, no difference in terms of average fertility by height were found, but there were small differences in timing of childbirth, possibly as a result of delayed marriage.

Adaptation and evidence of validity of the Corporate Ethical Virtues Scale in Brazil: A measure of ethical culture in organisations / Adaptación y evidencias de validez de la Escala de Virtudes Éticas Corporativas en Brasil: una medida de la cultura ética en las organizaciones

Abstract Introduction: Ethical culture stands out as an important variable in comprehending ethical norms and ethical behaviour at work. The Corporate Ethical Virtues (CEV) Scale is a widely used measure of ethical culture in organisations. This study aimed to adapt and validate the CEV Scale to a Brazilian context. Method: In Study 1 (n = 1.219), the CEV Scale was translated and adapted, the reliability and the internal structure were tested and the discriminant validity of ethical climate measures was demonstrated. In Study 2 (n = 635), measurement invariance in two groups was demonstrated, and there was evidence of validity based on the relationships with related constructs. Results: The results indicated that the Brazilian version of the CEV Scale showed reasonable psychometric properties and provided evidence of convergent and discriminant validity. Conclusion: This measure can be used by managers and consultants to diagnose ethical organisational culture.

Resumen Introducción: La cultura ética se destaca como una variable importante para comprender las normas y el comportamiento éticos en el trabajo. La escala de virtudes éticas corporativas (CEV) es una medida de cultura ética organizacional ampliamente utilizada. El objetivo de este estudio fue adaptar y validar la escala CEV de cultura ética al entorno brasileño. Método: En el estudio 1 (n = 1.219), la Escala CEV fue traducida y adaptada, se probaron la confiabilidad y la estructura interna y se demostró la validez discriminante de las medidas de clima ético. En el estudio 2 (n = 635), se demostró la invariancia de medición en dos grupos y hubo evidencia de validez basada en las relaciones con constructos relacionados. Resultados: Los resultados indicaron que la versión brasileña de la escala CEV mostró propiedades psicométricas razonables y proporcionó evidencia de validez convergente y discriminante. Conclusión: Esta medida puede ser utilizada por gerentes y consultores para diagnosticar la cultura organizacional ética.

The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses.

Genome-wide screens are powerful approaches to unravel regulators of viral infections. Here, a CRISPR screen identifies the RNA helicase DDX42 as an intrinsic antiviral inhibitor of HIV-1. Depletion of endogenous DDX42 increases HIV-1 DNA accumulation and infection in cell lines and primary cells. DDX42 overexpression inhibits HIV-1 infection, whereas expression of a dominant-negative mutant increases infection. Importantly, DDX42 also restricts LINE-1 retrotransposition and infection with other retroviruses and positive-strand RNA viruses, including CHIKV and SARS-CoV-2. However, DDX42 does not impact the replication of several negative-strand RNA viruses, arguing against an unspecific effect on target cells, which is confirmed by RNA-seq analysis. Proximity ligation assays show DDX42 in the vicinity of viral elements, and cross-linking RNA immunoprecipitation confirms a specific interaction of DDX42 with RNAs from sensitive viruses. Moreover, recombinant DDX42 inhibits HIV-1 reverse transcription in vitro. Together, our data strongly suggest a direct mode of action of DDX42 on viral ribonucleoprotein complexes. Our results identify DDX42 as an intrinsic viral inhibitor, opening new perspectives to target the life cycle of numerous RNA viruses.

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.

CRISPR knockout (KO) screens have identified host factors regulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication. Here, we conducted a meta-analysis of these screens, which showed a high level of cell-type specificity of the identified hits, highlighting the necessity of additional models to uncover the full landscape of host factors. Thus, we performed genome-wide KO and activation screens in Calu-3 lung cells and KO screens in Caco-2 colorectal cells, followed by secondary screens in four human cell lines. This revealed host-dependency factors, including AP1G1 adaptin and ATP8B1 flippase, as well as inhibitors, including mucins. Interestingly, some of the identified genes also modulate Middle East respiratory syndrome coronavirus (MERS-CoV) and seasonal human coronavirus (HCoV) (HCoV-NL63 and HCoV-229E) replication. Moreover, most genes had an impact on viral entry, with AP1G1 likely regulating TMPRSS2 activity at the plasma membrane. These results demonstrate the value of multiple cell models and perturbational modalities for understanding SARS-CoV-2 replication and provide a list of potential targets for therapeutic interventions.

Epitranscriptomic regulation of HIV-1 full-length RNA packaging.

During retroviral replication, the full-length RNA serves both as mRNA and genomic RNA. However, the mechanisms by which the HIV-1 Gag protein selects the two RNA molecules that will be packaged into nascent virions remain poorly understood. Here, we demonstrate that deposition of N6-methyladenosine (m6A) regulates full-length RNA packaging. While m6A deposition by METTL3/METTL14 onto the full-length RNA was associated with increased Gag synthesis and reduced packaging, FTO-mediated demethylation promoted the incorporation of the full-length RNA into viral particles. Interestingly, HIV-1 Gag associates with the RNA demethylase FTO in the nucleus and contributes to full-length RNA demethylation. We further identified two highly conserved adenosines within the 5'-UTR that have a crucial functional role in m6A methylation and packaging of the full-length RNA. Together, our data propose a novel epitranscriptomic mechanism allowing the selection of the HIV-1 full-length RNA molecules that will be used as viral genomes.

Did parental care in early life affect height? Evidence from rural Spain (19th-20th centuries).

This article examines the relationship between childhood mortality experienced within families and the height of surviving male children. Sibling mortality, controlled by different socioeconomic and environmental variables, is used as an approximation of the hygienic and epidemiological context and practices within the family. The analysis is based on a sample of 2783 individuals born between 1835 and 1977 in 14 villages in north-eastern Spain. The mortality data were obtained from the parish archives of the reference villages, and the height data from military service records of conscriptions at 21 years of age. The data were linked according to nominative criteria using family reconstitution methods. The results suggest the existence of a strong negative relationship between height and the childhood mortality experienced within families. Children born in families in which 50% of the children died before the age of five were up to 2.3 cm shorter than those of families with childhood mortality of less than 25%. General socioeconomic, hygienic and health improvements reduced childhood mortality, causing this link to gradually disappear between the 1940s and 1970s.

Rethinking the Fertility Transition in Rural Aragón (Spain) Using Height Data.

Based on an analysis of the life trajectories of 2510 conscripts and their families from a Spanish rural area in the period 1835-1977, this paper studies the development of the fertility transition in relation to height using bivariate analyses. The use of heights is an innovative perspective of delving into the fertility transition and social transformation entailed. The results confirm that the men with a low level of biological well-being (related to low socio-economic groups) were those who started to control their fertility, perhaps due to the effect that increased average family size had on their budget. The children of individuals who controlled their fertility were taller than the children of other families. Therefore, the children of parents who controlled their fertility experienced the largest intergenerational increase in height (approximately 50% higher). This increase could be due to the consequence of a greater investment in children (Becker's hypothesis) or a greater availability of resources for the whole family (resource dilution hypothesis).

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs.

Several genome-wide CRISPR knockout screens have been conducted to identify host factors regulating SARS-CoV-2 replication, but the models used have often relied on overexpression of ACE2 receptor. Additionally, such screens have yet to identify the protease TMPRSS2, known to be important for viral entry at the plasma membrane. Here, we conducted a meta-analysis of these screens and showed a high level of cell-type specificity of the identified hits, arguing for the necessity of additional models to uncover the full landscape of SARS-CoV-2 host factors. We performed genome-wide knockout and activation CRISPR screens in Calu-3 lung epithelial cells, as well as knockout screens in Caco-2 intestinal cells. In addition to identifying ACE2 and TMPRSS2 as top hits, our study reveals a series of so far unidentified and critical host-dependency factors, including the Adaptins AP1G1 and AP1B1 and the flippase ATP8B1. Moreover, new anti-SARS-CoV-2 proteins with potent activity, including several membrane-associated Mucins, IL6R, and CD44 were identified. We further observed that these genes mostly acted at the critical step of viral entry, with the notable exception of ATP8B1, the knockout of which prevented late stages of viral replication. Exploring the pro- and anti-viral breadth of these genes using highly pathogenic MERS-CoV, seasonal HCoV-NL63 and -229E and influenza A orthomyxovirus, we reveal that some genes such as AP1G1 and ATP8B1 are general coronavirus cofactors. In contrast, Mucins recapitulated their known role as a general antiviral defense mechanism. These results demonstrate the value of considering multiple cell models and perturbational modalities for understanding SARS-CoV-2 replication and provide a list of potential new targets for therapeutic interventions.

The association between male height and lifespan in rural Spain, birth cohorts 1835-1939.

This article analyses the relationship between male height and age at death and its evolution over time among conscripts born in fourteen villages in north-east rural Spain. A total of 1,488 conscripts born between 1835 and 1939 (and who died between 1868 and 2019) have been included in the analysis (based on the study of 3 sub-periods: 1835-1869, 1870-1899, and 1900-1939). The height data have been obtained from military service conscription records and the demographic and socioeconomic information of the deceased was obtained from parish archives and censuses. The data have been linked according to nominative criteria using family reconstitution methods. For the statistical analysis, we have used ordinary least squares (OLS) linear regressions with heteroskedasticity-robust estimation. The results suggest a positive relationship between height and lifespan in the long-term. For the birth cohorts of 1835-1869, conscripts with a height of 170 cm or more lived on average 7.6 years longer than conscripts measuring less than 160 cm. This difference in life expectancy tended to disappear for the birth cohorts of 1900-1939, benefiting especially the short conscripts who had greater possibilities to increase their average lifespan. The reasons that might explain these changes could reside in the improvements experienced by this group in terms of their living conditions, health and nutrition during the twentieth century.

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses.

Several genome-wide CRISPR knockout screens have been conducted to identify host factors regulating SARS-CoV-2 replication, but the models used have often relied on overexpression of ACE2 receptor. Additionally, such screens have yet to identify the protease TMPRSS2, known to be important for viral entry at the plasma membrane. Here, we conducted a meta-analysis of these screens and showed a high level of cell-type specificity of the identified hits, arguing for the necessity of additional models to uncover the full landscape of SARS-CoV-2 host factors. We performed genome-wide knockout and activation CRISPR screens in Calu-3 lung epithelial cells, as well as knockout screens in Caco-2 intestinal cells. In addition to identifying ACE2 and TMPRSS2 as top hits, our study reveals a series of so far unidentified and critical host-dependency factors, including the Adaptins AP1G1 and AP1B1 and the flippase ATP8B1. Moreover, new anti-SARS-CoV-2 proteins with potent activity, including several membrane-associated Mucins, IL6R, and CD44 were identified. We further observed that these genes mostly acted at the critical step of viral entry, with the notable exception of ATP8B1, the knockout of which prevented late stages of viral replication. Exploring the pro- and anti-viral breadth of these genes using highly pathogenic MERS-CoV, seasonal HCoV-NL63 and -229E and influenza A orthomyxovirus, we reveal that some genes such as AP1G1 and ATP8B1 are general coronavirus cofactors. In contrast, Mucins recapitulated their known role as a general antiviral defense mechanism. These results demonstrate the value of considering multiple cell models and perturbational modalities for understanding SARS-CoV-2 replication and provide a list of potential new targets for therapeutic interventions.

CBP80/20-dependent translation initiation factor (CTIF) inhibits HIV-1 Gag synthesis by targeting the function of the viral protein Rev.

Translation initiation of the human immunodeficiency virus type-1 (HIV-1) full-length RNA has been shown to occur through cap-dependent and IRES-driven mechanisms. Previous studies suggested that the nuclear cap-binding complex (CBC) rather than eIF4E drives cap-dependent translation of the full-length RNA and we have recently reported that the CBC subunit CBP80 supports the function of the viral protein Rev during nuclear export and translation of this viral transcript. Ribosome recruitment during CBC-dependent translation of cellular mRNAs relies on the activity CBP80/20 translation initiation factor (CTIF), which bridges CBP80 and the 40S ribosomal subunit through interactions with eIF3g. Here, we report that CTIF inhibits HIV-1 and HIV-2 Gag synthesis from the full-length RNA. Our results indicate that CTIF associates with HIV-1 Rev through its N-terminal domain and is recruited onto the full-length RNA ribonucleoprotein complex in order to interfere with Gag synthesis. We also demonstrate that CTIF induces the cytoplasmic accumulation of Rev impeding the association of the viral protein with CBP80. We finally show that Rev interferes with the association of CTIF with CBP80 indicating that CTIF and Rev compete for the CBC subunit.

Developing mindful organizing in teams: a participation climate is not enough, teams need to feel safe to challenge their leaders / El desarrollo de la organización consciente en equipos: un clima de participación no basta, los equipos necesitan sentir seguridad para realizar propuestas críticas a sus líderes

Mindful organizing (also known as collective mindfulness) is a collective capability that allows teams to anticipate and swiftly recover from unexpected events. This collective capability is especially relevant in high-risk environments where reliability in performance is of utmost importance. In this paper, we build on current mindful organizing theory by showing how two front-line communication and participatory conditions (perceived safety for upward dissent and climate for employee engagement) interact to predict mindful organizing. We shed light on the controversy around mindful organizing's effect on team's subjective experience at work by showing that it leads to greater team job satisfaction and thus lowers individual turnover intentions. These relationships were tested using a time-lagged design with two data-collection points using a sample of 47 teams within the nuclear power industry

La organización consciente en equipos es una capacidad colectiva que permite a los equipos anticipar y recuperarse rápidamente de eventos inesperados. Esta capacidad colectiva es especialmente relevante en entornos de alto riesgo donde la fiabilidad en el desempeño es de máxima importancia. En este artículo contribuimos al desarrollo de la teoría de la organización consciente mostrando cómo interactúan dos condiciones de participación y comunicación en la primera línea (seguridad percibida para elevar propuestas críticas y clima de participación) para predecir la organización consciente. Además, arrojamos luz sobre la controversia acerca de los efectos de la organización consciente en la experiencia subjetiva de los equipos en el trabajo, mostrando que lleva a mayor satisfacción laboral del equipo y en consecuencia disminuye la propensión de abandonar la organización a nivel individual. Estas relaciones se pusieron a prueba con un diseño de intervalo temporal con dos momentos de recogida de datos usando una muestra de 47 equipos del sector de la energía nuclear

Safety culture and safety performance in high-reliability organizations: a synthesis of IDOCAL’S contributions to the literature / Cultura de segurança e desempenho de segurança em organizações de alta confiabilidade: uma síntese das contribuições do IDOCAL para a literatura / Cultura de seguridad y desempeño de seguridad en organizaciones de alta fiabilidad: una síntesis de las contribuciones de IDOCAL a la literatura

Improving safety culture and safety performance is a constant concern for companies operating in high-risk environments. For almost two decades, IDOCAL (the Research Institute of Personnel Psychology, Organizational Development and Quality of Working Life) has been contributing to advancing our understanding of these important concepts through theoretical development and empirical research. The objective of this article is to synthesize these contributions. Some of the most prominent are (1) the development of a framework for the evaluation of safety culture and its correlates based on the AMIGO model, (2) the establishment of the empowering leadership model as a valuable concept in safety leadership, and (3) the establishment of a three-dimensional safety performance model. In addition, the researchers within IDOCAL have made great progress in understanding the main predictors of safety performance, including empowering leadership and safety culture. Within this paper, IDOCAL's plans to advance this line of research in the coming years, by extending it from the nuclear power sector to other high-risk industries, are also outlined.

Melhorar a cultura de segurança e o desempenho de segurança é uma preocupação constante para empresas que operam em ambientes de alto risco. Há quase duas décadas, o IDOCAL (Instituto de Pesquisa em Psicologia do Pessoal, Desenvolvimento Organizacional e Qualidade de Vida no Trabalho) tem contribuído para o avanço da compreensão desses importantes conceitos por meio do desenvolvimento teórico e da pesquisa empírica. O objetivo deste artigo é sintetizar essas contribuições. Alguns dos mais proeminentes são (1) o desenvolvimento de uma estrutura para a avaliação da cultura de segurança e seus correlatos com base no modelo AMIGO, (2) o estabelecimento do modelo de liderança capacitadora como um conceito valioso em liderança de segurança, e (3) o estabelecimento de um modelo tridimensional de desempenho de segurança. Além disso, os pesquisadores do IDOCAL fizeram um grande progresso no entendimento dos principais preditores de desempenho de segurança, incluindo capacitação de liderança e cultura de segurança. Neste documento, os planos do IDOCAL para avançar esta linha de pesquisa nos próximos anos, estendendo-a do setor de energia nuclear a outras indústrias de alto risco, também são descritos.

Mejorar la cultura de la seguridad y el desempeño de seguridad es una preocupación constante para las empresas que operan en entornos de alto riesgo. Durante casi dos décadas, IDOCAL (el Instituto de Investigación en Psicología de los Recursos Humanos, Desarrollo Organizacional y Calidad de Vida Laboral) ha contribuido a mejorar nuestra comprensión de estos importantes conceptos a través del desarrollo teórico y la investigación empírica. El objetivo de este artículo es sintetizar estos aportes. Algunos de los más destacados son (1) el desarrollo de un marco para la evaluación de la cultura de la seguridad y sus correlatos basado en el modelo AMIGO, (2) el establecimiento del modelo de liderazgo empoderador como un concepto valioso en el liderazgo en seguridad, y (3) el establecimiento de un modelo tridimensional de desempeño de seguridad. Además, los investigadores de IDOCAL han logrado grandes avances en la comprensión de los principales predictores del desempeño en seguridad, incluido el liderazgo de empoderamiento y la cultura de seguridad. En este trabajo también se describen los planes de IDOCAL para avanzar en esta línea de investigación en los próximos años, extendiéndola desde el sector de la energía nuclear a otras industrias de alto riesgo.

Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway.

BACKGROUND: Patients with liver cirrhosis may develop hepatic encephalopathy. Rats with chronic hyperammonemia exhibit neurological alterations mediated by peripheral inflammation and neuroinflammation. Motor incoordination is due to increased TNF-a levels and activation of its receptor TNFR1 in the cerebellum. The aims were to assess (a) whether peripheral inflammation is responsible for TNF-a induction in hyperammonemic rats, (b) the cell type(s) in which TNF-a is increased, (c) whether this increase is associated with increased nuclear NF-κB and TNFR1 activation, (d) the time course of TNF-a induction, and (e) if TNF-a is induced in the Purkinje neurons of patients who die with liver cirrhosis. METHODS: We analyzed the level of TNF-a mRNA and NF-κB in microglia, astrocytes, and Purkinje neurons in the cerebellum after 1, 2, and 4 weeks of hyperammonemia. We assessed whether preventing peripheral inflammation by administering an anti-TNF-a antibody prevents TNF-a induction. We tested whether TNF-a induction is reversed by R7050, which inhibits the TNFR1-NF-κB pathway, in ex vivo cerebellar slices. RESULTS: Hyperammonemia induced microglial and astrocyte activation at 1 week. This was followed by TNF-a induction in both glial cell types at 2 weeks and in Purkinje neurons at 4 weeks. The level of TNF-a mRNA increased in parallel with the TNF-a protein level, indicating that TNF-a was synthesized in Purkinje cells. This increase was associated with increased NF-κB nuclear translocation. The nuclear translocation of NF-κB and the increase in TNF-a were reversed by R7050, indicating that they were mediated by the activation of TNFR1. Preventing peripheral inflammation with an anti-TNF-a antibody prevents TNF-a induction. CONCLUSION: Sustained (4 weeks) but not short-term hyperammonemia induces TNF-a in Purkinje neurons in rats. This is mediated by peripheral inflammation. TNF-a is also increased in the Purkinje neurons of patients who die with liver cirrhosis. The results suggest that hyperammonemia induces TNF-a in glial cells and that TNF-a released by glial cells activates TNFR1 in Purkinje neurons, leading to NF-κB nuclear translocation and the induction of TNF-a expression, which may contribute to the neurological alterations observed in hyperammonemia and hepatic encephalopathy.

Revisiting the effect of time of birth on neonatal, infant, and child mortality in rural Spain, 1830-1929.

OBJECTIVES: This article aims to determine whether different patterns of mortality occurred among children born during the day and the night respectively, between 1830 and 1929. METHODS: The data include the time of birth and death of 9814 individuals from 10 villages in rural Spain between 1830 and 1929, within a context of natural births at home with little medical support. These data were subjected to a comparative analysis relating to the time of birth and the age at death. RESULTS: Neonatal, infant, and child mortality was higher for children born during daytime. The day-to-night mortality pattern diverged until children were at least 5 years old. CONCLUSIONS: The results confirm that the mortality patterns differed according to the time of birth. Possibly some of these children experienced longer or problematic deliveries that, in the absence of good medical assistance, had health consequences during the following days and years of life.

Spanish validation of the mindful organizing scale: A questionnaire for the assessment of collective mindfulness.

INTRODUCTION: Mindful organizing (also known as collective mindfulness) is a team level construct that is said to underpin the principles of high-reliability organizations (HROs), as it has shown to lead to almost error-free performance. While mindful organizing research has proliferated in recent years, studies on how to measure mindful organizing are scarce. Vogus and Sutcliffe (2007) originally validated a nine-item "Mindful Organizing Scale" but few subsequent validation studies of this scale exist. The present study aimed to validate a Spanish version of the Mindful Organizing Scale. METHOD: The sample included 47 teams (comprising of a total of 573 workers with an average team size of 12.19) from a Spanish nuclear power plant. A confirmatory factor analysis (CFA), reliability analysis, and an analysis of aggregation indices were carried out. A correlation analysis and CFA were used to further validate the scale in terms of its distinctiveness from, and relationship with, other team-related variables such as safety culture, team safety climate, and team learning. Finally, evidence of criterion-related validity was collected by testing the incremental validity of the mindful organizing scale in the association with various workplace safety outcomes (safety compliance and safety participation). RESULTS: The results confirmed a unidimensional structure of the scale and indicated satisfactory internal consistency. Aggregation of the scores to the team level was justified while significant positive correlations between mindful organizing and other team-related variables (safety culture, team safety climate, team learning) were found. Moreover, mindful organizing showed distinctiveness from safety culture, team safety climate and team learning. Finally, incremental validity of the scale was supported, as it shows to be associated with safety compliance and safety participation above and beyond other related constructs. CONCLUSIONS: The Spanish version of the Mindful Organizing Scale has shown to be a valid and reliable scale that can be used to measure mindful organizing. CONTRIBUTIONS: The validation of the unidimensional Spanish version of Vogus and Sutcliffe's (2007) Mindful Organizing Scale provides researchers and practitioners with a reliable and valid tool to use in Spanish speaking organizations to measure mindful organizing, which has been shown to result in more reliable performance. Theoretically, this study offers four contributions. Firstly, it validates a scale that operationalizes the 'mindful organizing' construct in a traditional high-reliability organization (nuclear power plant) which has never been done before. Secondly, it offers evidence that a mindful organizing scale can be validated in a new cultural context and language (Spanish) to any of the previous studies done before it. Thirdly, it adds to our understanding of mindful organizing's nomological network by distinguishing it from other team and safety-related variables. Lastly, it builds on current research showing sound psychometric properties of a one-dimensional, quantitative measure of mindful organizing.